Peter Parker is torn between maintaining his normal life and continuing his career as Spider-Man. Trouble rises when Mojo Jojo and Dr. Eggman return, this time with the aid of a new villain, Doctor Octopus. To make matters worse, they bring back the Loud kids and Gizmo's old enemy, Stripe. Can Spider-Man and Team Powerpuff save the day again from the four bad guys?
The Powerpuff Girls: Blossom, Bubbles, & Buttercup
The Chipmunks: Alvin, Simon, & Theodore
Garfield & Odie
The Teenage Mutant Ninja Turtles: Leonardo, Donatello, Raphael, & Michelangelo
Yoshino Fujieda & Lalamon
Sonic the Hedgehog & Miles "Tails" Prower
The Loud Kids: Lincoln, Lori, Leni, Luna, Luan, Lynn, Lucy, Lola, Lana, Lisa, & Lily